In Cell Interactome of Oleocanthal, an Extra Virgin Olive Oil Bioactive Component.

نویسندگان

  • Chiara Cassiano
  • Agostino Casapullo
  • Alessandra Tosco
  • Maria Chiara Monti
  • Raffaele Riccio
چکیده

A copper-(I)-catalyzed variation of the Huisgen 1,3-dipolar cycloaddition has been applied to lead the in living-cell mass-spectrometry based identification of protein targets of oleocanthal, a natural metabolite daily ingested by millions of people. Chemical proteomics revealed heat-shock proteins, HSP70 and HSP90, as main oleocanthal interactors in living systems. These two proteins are involved in cancer development and, thus, our findings could have important outcomes for a deep evaluation of the bio-pharmacological significance of oleocanthal.

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عنوان ژورنال:
  • Natural product communications

دوره 10 6  شماره 

صفحات  -

تاریخ انتشار 2015